What it's used for
Carbidopa and levodopa extended-release tablets are used to treat Parkinson's disease. They are also prescribed for post-encephalitic parkinsonism and symptomatic parkinsonism following carbon monoxide or manganese intoxication.
Source: U.S. FDA-approved prescribing information (openFDA).
Typical dosing
The daily dosage must be determined by careful titration, utilizing tablets containing carbidopa and levodopa in a 1:4 ratio.
Dosing shown here is the general FDA-labeled range. Your prescribing clinician determines the exact dose, form, and schedule for you — this is not a substitute for medical advice.
Boxed warning / key safety info
When switching from levodopa without a decarboxylase inhibitor, levodopa must be discontinued at least twelve hours before starting this medication.
Common side effects
The adverse experience profile of the extended-release formulation is similar to that of immediate-release formulations, involving motor fluctuations and related symptoms.
Covered strengths on the Tab $0 list
Covered at $0 with an active Tab membership when filled at a participating pharmacy nationwide or through mail order. A licensed clinician must prescribe the medication.
Related medications
Other everything else medications covered at $0 with an active Tab membership.
Carbidopa/Levodopa cost without insurance
Cash prices for Carbidopa/Levodopa without insurance vary widely by pharmacy, strength and quantity — the same prescription can cost very different amounts at two pharmacies in the same town. That is the problem a membership solves.
Carbidopa/Levodopa is on Tab's covered $0 generic list. With an active Tab membership, every covered strength is $0 — not a percentage off, not a coupon that changes month to month — at participating pharmacies nationwide or through mail order. You do not need insurance, and Tab works whether or not you have a health plan.
Tab is a membership, not insurance. Covered medications require a prescription from a licensed clinician.
Carbidopa/Levodopa dosage and administration
Carbidopa, levodopa and entacapone tablets should be used as a substitute for patients already stabilized on equivalent doses of carbidopa/levodopa and entacapone. However, some patients who have been stabilized on a given dose of carbidopa/levodopa may be treated with carbidopa, levodopa and entacapone tablets if a decision has been made to add entacapone (see below). Therapy should be individualized and adjusted according to the desired therapeutic response. Evaluate vitamin B6 levels prior to starting treatment with carbidopa/levodopa therapies. ( 2.1 ) The optimum daily dosage of carbidopa, levodopa and entacapone tablets must be determined by careful titration in each patient ( 2.2 ) Individual tablets should not be split or fractionated.
Excerpt from the FDA-approved prescribing information (openFDA), retrieved 2026-09-15. Your prescribing clinician decides the exact dose, form and schedule for you — this is not medical advice.
Carbidopa/Levodopa side effects
The following adverse reactions are discussed in more detail in the Warnings and Precautions sections of labeling: Falling Asleep During Activities of Daily Living and Somnolence [ see Warnings and Precautions (5.1) ] Hypotension/Orthostatic Hypotension and Syncope [ see Warnings and Precautions (5.2) ] Dyskinesia [ see Warnings and Precautions (5.3) ] Depression and suicidality [ see Warnings and Precautions (5.4) ] Hallucinations/Psychotic-Like Behavior [ see Warnings and Precautions (5.5) ] Impulse Control and/or Compulsive Behaviors [ see Warnings and Precautions (5.6) ] Withdrawal-Emergent Hyperpyrexia and Confusion [ see Warnings and Precautions (5.7) ] Diarrhea and Colitis [ see Warnings and Precautions (5.8) ] Rhabdomyolysis [ see Warnings and Precautions (5.9) ] Vitamin B6 Deficiency and Seizures [ see Warnings and Precautions (5.10) ] Peptic Ulcer Disease [ see Warnings and Precautions (5.13) ] The most common adverse reactions (incidence 3% higher than placebo incidence) are dyskinesias, hyperkinesia, diarrhea, nausea, abdominal pain, vomiting, dry mouth, and urine discoloration ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Rising Pharma Holdings, Inc.
Excerpt from the FDA-approved prescribing information (openFDA), retrieved 2026-09-15. This is not a complete list. Report side effects to your clinician, and seek care for anything severe or unexpected.
Carbidopa/Levodopa drug interactions
Drugs metabolized by COMT: use with caution ( 5.11 , 7.2 ) Anti-hypertensive agents: dose adjustment may be required ( 7.3 ) Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 ) Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa, levodopa and entacapone tablets ( 7.5 , 7.6 , 7.7 , 7.8 , 7.9 ) Drugs that interfere with biliary excretion, glucuronidation and intestinal beta-glucuronidase: dose adjustment of carbidopa, levodopa and entacapone tablets may be required ( 7.10 ) Drugs metabolized by CYP2C9 (e.g., coumadin): dose adjustment of carbidopa, levodopa and entacapone tablets may be required;
Excerpt from the FDA-approved prescribing information (openFDA), retrieved 2026-09-15. Tell your clinician and pharmacist about every medication, supplement and over-the-counter product you take.
Who should not take carbidopa/levodopa
Carbidopa, levodopa and entacapone tablets are contraindicated in patients: Taking nonselective monoamine oxidase (MAO) inhibitors (e.g., phenelzine and tranylcypromine). These nonselective MAO inhibitors must be discontinued at least two weeks prior to initiating therapy with carbidopa, levodopa and entacapone tablets. With narrow-angle glaucoma. Concomitant use of nonselective monoamine oxidase (MAO) inhibitors ( 4 ) Narrow-angle glaucoma ( 4 )
Excerpt from the FDA-approved prescribing information (openFDA), retrieved 2026-09-15. Whether this medication is appropriate for you is a clinical decision made by your prescribing clinician.
Common questions
Is carbidopa/Levodopa covered at $0 with Tab?
Yes. Carbidopa/Levodopa is on Tab's covered $0 generic list — every covered strength is $0 with an active membership, at participating pharmacies nationwide or by mail order.
Do I need insurance to get carbidopa/Levodopa through Tab?
No. Tab is a membership, not insurance. Covered medications are $0 with an active membership whether or not you have a health plan.
How do I get a carbidopa/Levodopa prescription with Tab?
Book a video visit with a licensed Tab clinician (unlimited visits are included with membership). If it's clinically appropriate, they send the prescription to your chosen participating pharmacy or by mail order.
How much does carbidopa/levodopa cost without insurance?
Without insurance, retail cash prices for carbidopa/levodopa vary by pharmacy, strength and quantity. Carbidopa/Levodopa is on Tab's covered $0 generic list, so every covered strength is $0 with an active Tab membership at participating pharmacies nationwide or by mail order.
What is the cheapest way to get carbidopa/levodopa?
For medications on Tab's covered list, a Tab membership is the cheapest route: covered strengths of carbidopa/levodopa are $0 with an active membership, and unlimited video visits with a licensed clinician are included, so the visit that produces the prescription is covered too.
What is the usual dose of carbidopa/levodopa?
Carbidopa, levodopa and entacapone tablets should be used as a substitute for patients already stabilized on equivalent doses of carbidopa/levodopa and entacapone. However, some patients who have been stabilized on a given dose of carbidopa/levodopa may be treated with carbidopa, levodopa and entacapone tablets if a decision has been made to add entacapone (see below). (FDA-approved label, retrieved 2026-09-15. Your clinician sets your dose.)
What are the side effects of carbidopa/levodopa?
The following adverse reactions are discussed in more detail in the Warnings and Precautions sections of labeling: Falling Asleep During Activities of Daily Living and Somnolence [ see Warnings and Precautions (5.1) ] Hypotension/Orthostatic Hypotension and Syncope [ see Warnings and Precautions (5.2) ] Dyskinesia [ see Warnings and Precautions (5.3) ] Depression and suicidality [ see Warnings and Precautions (5.4) ] Hallucinations/Psychotic-Like Behavior [ see Warnings and Precautions (5.5) ] Impulse Control and/or Compulsive Behaviors [ see Warnings and Precautions (5.6) ] Withdrawal-Emergent Hyperpyrexia and Confusion [ see Warnings and Precautions (5.7) ] Diarrhea and Colitis [ see Warnings and Precautions (5.8) ] Rhabdomyolysis [ see Warnings and Precautions (5.9) ] Vitamin B6 Deficiency and Seizures [ see Warnings and Precautions (5.10) ] Peptic Ulcer Disease [ see Warnings and Precautions (5.13) ] The most common adverse reactions (incidence 3% higher than placebo incidence) are dyskinesias, hyperkinesia, diarrhea, nausea, abdominal pain, vomiting, dry mouth, and urine discoloration ( 6.1 ) To report SUSPECTED ADVERSE REACTIONS, contact Rising Pharma Holdings, Inc. (FDA-approved label, retrieved 2026-09-15.)
What interacts with carbidopa/levodopa?
Drugs metabolized by COMT: use with caution ( 5.11 , 7.2 ) Anti-hypertensive agents: dose adjustment may be required ( 7.3 ) Tricyclic antidepressants: risk of hypertension and dyskinesia reported during concomitant use with carbidopa/levodopa ( 7.4 ) Dopamine D2 receptor antagonists, isoniazid, phenytoin, papaverine and iron salts: may reduce efficacy of carbidopa, levodopa and entacapone tablets ( 7.5 , 7.6 , 7.7 , 7.8 , 7.9 ) Drugs that interfere with biliary excretion, glucuronidation and intestinal beta-glucuronidase: dose adjustment of carbidopa, levodopa and entacapone tablets may be required ( 7.10 ) Drugs metabolized by CYP2C9 (e.g., coumadin): dose adjustment of carbidopa, levodopa and entacapone tablets may be required; (FDA-approved label, retrieved 2026-09-15. Tell your clinician about every medication and supplement you take.)
Carbidopa/Levodopa is $0 on the covered list
Members pay $0 for covered generics at participating pharmacies nationwide or by mail order — plus unlimited virtual primary care, urgent care and dermatology visits. No insurance needed.
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